United Kingdom Launches £75 Million National Roadmap to Phase Out Animal Testing by 2030: A Defining Moment for Human-Relevant Research

Abstract

On 11 November 2025, the United Kingdom released its unprecedented “Roadmap for Replacing Animals in  Science”, announcing a structured transition toward humanrelevant, non-animal scientific methods by 2030.  Supported by £75 million in dedicated government funding, the roadmap positions organoids,  microphysiological systems (MPS), AI-driven toxicology, and advanced in vitro human models as central  components of future regulatory science. This article summarizes key milestones, scientific frameworks,  regulatory mechanisms, and sector-wide implications of the UK roadmap. The initiative represents one of the  most comprehensive national strategies for animal testing reduction ever implemented by a G7 country,  oering a blueprint for global transition toward human-specific research platforms.