Unlocking the Potential of Organoid Models in Ferroptosis: A Breakthrough in Cancer Research

Abstract

Ferroptosis, a regulated form of cell death driven by iron-dependent lipid peroxidation, has emerged as a critical mechanism in cancer biology. Understanding the molecular mechanisms and experimental models of ferroptosis is essential for developing novel therapeutic strategies. Organoid models, which closely mimic the architecture and functionality of human tissues, offer a promising platform for studying ferroptosis in various cancer types. This review explores the construction and application of organoid models, highlighting their advantages in cancer research. We discuss the link between ferroptosis and organoids in various cancers, including colorectal cancer, pancreatic cancer, liver cancer, breast cancer, gastric cancer, ovarian cancer, and other cancers. Furthermore, we examine the therapeutic implications of ferroptosis in organoid models, emphasizing the potential for these models to enhance our understanding of cancer biology and improve treatment outcomes.